It has not escaped to notice that the most of Euroasian admixture had main proportion in Ethiopian populations (as seen in Fig2. For that reason, masked Euroasian admixture might affect only Ethiopian population, but certainly cannot be generalized for other African populations that actually might have had a process of local adaptation.Consequently, the quote from paper “This suggests that a large proportion of differentiation observed among African populations could be due to Euroasian admixture, rather than adaptation to selective forces.” should be taken .The variant in CKS gene region showed complete linkage disequilibrium (LD) with another risk allele that correlates with latitude, giving the evidence of temperature local adaptation as a mechanism of hypertension.Next, the authors were interested in comparison of populations situated in endemic and non-endemic regions to distinguish loci related to infectious diseases.Beside the comprehensive map of the African variants obtained from genotypes of 1,481 individuals and whole-genome sequences of 320 individuals, authors offered a design of the array suitable to capturing variants of African populations.
However, it was not commented in article do these populations have a presence of both admixtures or not and how is it possible.
In the article, authors suggested that the modest differentiation among Niger-Congo language group showed evidence for ‘Bantu expansion’.
However, the Fig1.a shows sample distribution mostly next to the Western, East and South African coasts, rather then inside of continent where the Bantu expansion occurred, therefore indicating the sampling bias. a, 18 African populations studied in the AGVP including 2 populations from the 1000 Genomes Project.
Beside some other locus-specific differentiations, they found evidence of differentiation in CR1 gene (chemokine receptor 1), previously reported as a gene implicated in malaria susceptibility.
The authors also identified locus-specific differentiation within genes active in osmoregulation, specifically in hypertension.
Nevertheless, the authors did not discuss other possibilities of gene flow effects, such as allele surfing or allele fixation.