Only low-risk compounding may occur under these circumstances, and the product must be administered within 1 hour.A pharmacist is not required to verify the sterility, stability, or accuracy of the final product.
In light of this call to ensure patient safety, hospital pharmacies have been evaluating their use of outsourcing and their own compliance with United States Pharmacopeial Convention (USP) chapter Microbial contamination of CSPs can occur in any practice setting and puts patients at risk of significant morbidity and mortality.
into state legislation and adoption of a policy of enforcement by the Joint Commission encouraged swift action and compliance on the part of hospitals and pharmacies across the country.
The chapter stratifies the compounding of all sterile products, including irrigations and ophthalmic preparations, into 3 risk levels based on the sterility of the bulk ingredients and the degree of manipulation required to make the final product.
It is important to note that some CSPs are prepared and administered in clinics, at the bedside, in procedural areas, and in operating rooms with little direct pharmacy oversight.
While quality and safety programs exist within other health care professions, pharmacy knowledge and involvement in these activities ensures compliance with best practices and also provides an opportunity for pharmacy to take ownership of the complete medication use process.
Despite the 9-year tenure of USP some of these practices persist as a result of their past success, convenience, and the comfort level of health care personnel.